3-Bromopyruvate (3bp) Therapy Is A Highly Effective Cancer Treatment 


3-bromopyruvate (3bp), the subject of a mini-review, is an incredibly powerful and swift acting anticancer agent.

3BP, a small molecule, results in a remarkable therapeutic effect when it comes to treating cancers exhibiting a “Warburg effect”. This includes most cancer types.


Warburg Effect: 

In oncology, the Warburg effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol, rather than by a comparatively low rate of glycolysis followed by oxidation of pyruvate in mitochondria as in most normal cells.

The pyruvate analogue 3-bromopyruvate (3-BP) is an electrophilic alkylator that is considered a promising anticancer drug because it has been shown to kill cancer cells efficiently while having little toxic effect on nontumor cells.

The pyruvate analog, 3-bromopyruvate, is an alkylating agent and a potent inhibitor of glycolysis. This antiglycolytic property of 3-bromopyruvate has recently been exploited to target cancer cells, as most tumors depend on glycolysis for their energy requirements. The anticancer effect of 3-bromopyruvate is achieved by depleting intracellular energy (ATP) resulting in tumor cell death. **

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* Footnotes: Research Articles Cited

Biomagnetic research provided by:

  • BioMagnetic Research and Technology (Biomed Central)
  • Hyperthermia using magnetite cationic liposomes for hamster Osteosarcoma
  • Fumiko Matsuoka1, Masashige Shinkai1, Hiroyuki Honda*1, Tadahiko Kubo2, Takashi Sugita2 and Takeshi Kobayashi1
  • http://www.biomedcentral.com/content/pdf/1477-044x-2-3.pdf


Enzyme research provided by:

  • The FASEB Journal / The Official Journal of the Federation of American Societies for Experimental Biology
  • Activation of prodrugs by antibody-enzyme conjugates: a new approach to cancer therapy.
  • P D Senter
  • February 1, 1990 The FASEB Journal vol. 4 no. 2 188-193
  • http://www.fasebj.org/content/4/2/188.short


Hyperthermia research provided by:


  •   European Journal of Cancer (1965)
  • Investigations on the possibility of a thermic tumour therapy—I.: Short-wave treatment of a transplanted isologous mouse mammary carcinoma
  • Volume 8, Issue 1, February 1972, Pages 65, Pages IN3, Pages 69-68-IN8-78
  • Presented in abbreviated form at the First Congress of the European Association for Cancer Research, Brussels, September 1970.
  • Kristian Overgaard, Jens Overgaard
  • http://www.sciencedirect.com/science/article/pii/0014296472900850

 

Insulin research provided by:

  • Journal of BUON 14: 711-715, 2009
  • © 2009 Zerbinis Medical Publications. Printed in Greece
  • Low dose chemotherapy in combination with insulin for the treatment of advanced
  • metastatic tumors. Preliminary experience
  • C. Damyanov, M. Radoslavova, V. Gavrilov, D. Stoeva
  • Medical Center of Integrative Medicine, Sofia, Bulgaria
  • http://integramed.org/BUONarticleDamyanov.pdf

 

 

Laser research provided by:

  • Cancer Research: The Journal of Cancer Research  /  The American Journal of Cancer
  • Laser Photoradiation Therapy of Cancer1
  • Anton Dahlman, Alan G. Wile2, Robert G. Burns, G. Robert Mason, Fred M. Johnson, and Michael W. Berns
  • http://cancerres.aacrjournals.org/content/43/1/430.short

 

  • CA:A Cancer Journal for Clinicians
  • Photodynamic therapy of cancer: An update
  • Patrizia Agostinis PhD1, Kristian Berg PhD2, Keith A. Cengel MD, PhD3, Thomas H. Foster PhD4, Albert W. Girotti PhD5, Sandra O. Gollnick PhD6, Stephen M. Hahn MD, PhD7, Michael R. Hamblin PhD8,9,10, Asta Juzeniene PhD11, David Kessel PhD12, Mladen Korbelik PhD13, Johan Moan PhD14,15, Pawel Mroz MD, PhD16,17, Dominika Nowis MD, PhD18, Jacques Piette PhD19, Brian C. Wilson PhD20 andJakub Golab MD, PhD21,22,*
  • Version of Record online: 26 MAY 2011
  • http://onlinelibrary.wiley.com/doi/10.3322/caac.20114/full

 

Sonodynamic research provided by:

 

  • Anticancer Research: International Journal of cancer research and treatment
  • The Real Deal: Using Cytochalasin B in Sonodynamic Therapy to Preferentially Damage Leukemia Cells
  • MATTHEW TRENDOWSKI, GUOWU YU, VICTORIA WONG, CHRISTOPHER ACQUAFONDATA,
  • TIMOTHY CHRISTEN and THOMAS P. FONDY
  • Department of Biology, Syracuse University, Syracuse, NY, U.S.A
  • http://ar.iiarjournals.org/content/34/5/2195.full.pdf+html

 

Immunotherapy research provided by:


Oxygen research provided by:

 

  • Anticancer Research / International Journal of Cancer Research and Treatment
  • Hyperbaric Oxygen Inhibits Benign and Malignant Human Mammary Epithelial Cell Proliferation
  • ERIC V. GRANOWITZ1, NORIKO TONOMURA2, RITA M. BENSON1, DEBORAH M. KATZ1, VIMLA BAND3, GRACE P. MAKARI-JUDSON1 and BARBARA A. OSBORNE2
  • http://ar.iiarjournals.org/content/25/6B/3833.short

 

 

Vitamin research provided by:


RIFE Technology research provided by:

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