3-Bromopyruvate (3bp) Therapy Is A Highly Effective Cancer Treatment
3-bromopyruvate (3bp), the subject of a mini-review, is an incredibly powerful and swift acting anticancer agent.
3BP, a small molecule, results in a remarkable therapeutic effect when it comes to treating cancers exhibiting a “Warburg effect”. This includes most cancer types.
In oncology, the Warburg effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol, rather than by a comparatively low rate of glycolysis followed by oxidation of pyruvate in mitochondria as in most normal cells.
The pyruvate analogue 3-bromopyruvate (3-BP) is an electrophilic alkylator that is considered a promising anticancer drug because it has been shown to kill cancer cells efficiently while having little toxic effect on nontumor cells.
The pyruvate analog, 3-bromopyruvate, is an alkylating agent and a potent inhibitor of glycolysis. This antiglycolytic property of 3-bromopyruvate has recently been exploited to target cancer cells, as most tumors depend on glycolysis for their energy requirements. The anticancer effect of 3-bromopyruvate is achieved by depleting intracellular energy (ATP) resulting in tumor cell death. **
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* Footnotes: Research Articles Cited
Biomagnetic research provided by:
BioMagnetic Research and Technology (Biomed Central)
Hyperthermia using magnetite cationic liposomes for hamster Osteosarcoma
Patrizia Agostinis PhD1, Kristian Berg PhD2, Keith A. Cengel MD, PhD3, Thomas H. Foster PhD4, Albert W. Girotti PhD5, Sandra O. Gollnick PhD6, Stephen M. Hahn MD, PhD7, Michael R. Hamblin PhD8,9,10, Asta Juzeniene PhD11, David Kessel PhD12, Mladen Korbelik PhD13, Johan Moan PhD14,15, Pawel Mroz MD, PhD16,17, Dominika Nowis MD, PhD18, Jacques Piette PhD19, Brian C. Wilson PhD20 andJakub Golab MD, PhD21,22,*
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